Do you have a family history of Huntington disease?

Huntington disease (HD) is an adult onset disorder involving progressive motor disability, cognitive decline, and personality changes. Because this is an autosomal dominant condition, a person with a parent with HD has about a 50% risk of developing HD. Many couples want to prevent having a child that will develop HD, but do not want to face the decision of prenatal testing and possible pregnancy interruption. Often, individuals do not know if they have HD when they are family planning because the average age of onset of clinical symptoms is 40 years old. These couples may want to prevent having a child with HD, but not know if they carry the HD gene. Non-Disclosing PGD for HD can help these couples decrease the chance of conceiving a pregnancy with HD while not identifying the HD status of the couple.

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